Energy reserve metabolic process

Across TCGA patient cohorts, RNA activity of the Energy reserve metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX21_S89, SRPX2, and PFN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Energy reserve metabolic process activity versus DDX21_S89 in BRCA (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX21_S89 →	-0.955	-0.029	<.001	<.001	3	6
BRCA	SRPX2 →	+0.698	+0.025	<.001	<.001	3	6
LUAD	PFN1 →	-0.124	-0.024	.007	.001	3	6
UCEC	CHAF1A_S141 →	-0.651	-0.044	<.001	<.001	3	5
BRCA	MKI67 →	-0.646	-0.027	<.001	<.001	3	5
UCEC	NCAPG_S674 →	-0.830	-0.033	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006112 vs DDX21_S89 — BRCA

Explore this scatter interactively →