Energy reserve metabolic process

Across TCGA cell cohorts, RNA activity of the Energy reserve metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD6, RRAGD, and ADAM11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Energy reserve metabolic process activity versus ANKRD6 in PANCREAS (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ANKRD6 →	+1.280	+0.910	<.001	.001	3	5
PANCREAS	RRAGD →	+1.254	+0.847	.009	.003	3	5
BLOOD_Leukemia	ADAM11 →	+0.636	+0.233	.001	.001	3	4
BLOOD_Leukemia	MYO5A →	+1.017	+0.267	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	NPDC1 →	+1.816	+1.213	.008	.002	3	4
PANCREAS	ZBTB10 →	+0.819	+0.925	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006112 vs ANKRD6 — PANCREAS

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