Regulation of glycolytic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycolytic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT1M, MRPL18, and COX7A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MT1M grouped by Regulation of glycolytic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MT1M →	-1.615	-0.164	.007	.005	3	4
LIVER	MRPL18 →	-0.651	-0.316	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	COX7A2 →	-1.268	-0.278	<.001	<.001	3	4
LIVER	PCGF6 →	-0.648	-0.296	.006	.002	3	4
LIVER	TIMM23 →	-0.559	-0.210	.005	.008	3	4
BREAST	BTN2A2 →	+1.462	+0.201	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MT1M by Regulation of glycolytic process activity — OVARY

Explore this box plot interactively →