Regulation of glycolytic process

Across TCGA cell cohorts, RNA activity of the Regulation of glycolytic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCHL1, RAB20, and TUB, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glycolytic process activity versus UCHL1 in LUNG_NSCLC_LUSC (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UCHL1 →	+6.620	+1.585	<.001	.008	3	11
BLOOD_Lymphoma	RAB20 →	-1.766	-0.929	.005	.001	3	6
LUNG_NSCLC_LUAD	TUB →	+1.667	+1.145	<.001	<.001	3	5
OESOPHAGUS	CRYBG1 →	-1.903	-1.210	.003	.001	2	6
SOFT_TISSUE	FST →	-3.241	-0.917	.001	.007	3	5
STOMACH	PIGB →	-0.660	-1.640	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006110 vs UCHL1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →