Regulation of carbohydrate metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of carbohydrate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_T506, LENG8_S351, and KPNA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of carbohydrate metabolic process activity versus RFC1_T506 in GBM (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC1_T506 →	-0.748	-0.031	.002	<.001	3	6
OV	LENG8_S351 →	-1.127	-0.028	<.001	.001	3	6
PDAC	KPNA2 →	-0.397	-0.021	<.001	.002	3	6
GBM	SPTAN1 →	+0.308	+0.035	.007	<.001	3	6
LSCC	RPL30_S10 →	-0.370	-0.027	.005	.001	3	5
COAD	CRYL1 →	+0.289	+0.011	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006109 vs RFC1_T506 — GBM

Explore this scatter interactively →