Regulation of carbohydrate metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of carbohydrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPO, UCHL1, and CENPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of carbohydrate metabolic process activity versus TSPO in STOMACH (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TSPO →	-2.455	-0.220	.006	.001	3	5
OESOPHAGUS	UCHL1 →	+4.692	+0.170	<.001	<.001	3	5
SOFT_TISSUE	CENPA →	+0.846	+0.185	.007	.001	3	4
OESOPHAGUS	SUCLG1 →	-0.697	-0.164	.003	.007	3	4
OESOPHAGUS	IMMP2L →	-1.294	-0.147	<.001	<.001	3	4
BLOOD_Leukemia	CBX5 →	+0.852	+0.150	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006109 vs TSPO — STOMACH

Explore this scatter interactively →