Malate metabolic process

Across TCGA patient cohorts, RNA activity of the Malate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDC, ALOX5, and MIR548H1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Malate metabolic process activity versus HDC in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HDC →	+1.592	+0.135	.007	.008	2	5
LSCC	ALOX5 →	+0.638	+0.108	<.001	.001	3	3
LUAD	MIR548H1 →	-0.517	-0.082	.002	.007	3	3
COAD	TMPO-AS1 →	-0.304	-0.157	.005	.001	3	3
BRCA	CNPY2 →	-0.334	-0.151	.001	.003	3	3
OV	WDR46 →	-0.379	-0.109	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006108 vs HDC — BRCA

Explore this scatter interactively →