Succinate metabolic process

Across TCGA patient cohorts, RNA activity of the Succinate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH5A1, HOGA1, and FSCN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinate metabolic process activity versus ALDH5A1 in LSCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ALDH5A1 →	+0.966	+0.124	<.001	<.001	3	6
PDAC	HOGA1 →	+0.430	+0.059	<.001	<.001	3	5
BRCA	FSCN1 →	-1.076	-0.108	<.001	<.001	3	5
LSCC	GPLD1 →	+0.696	+0.081	.001	.001	3	5
BRCA	LGALS1 →	-0.749	-0.075	<.001	<.001	3	4
HNSC	HLF →	+0.798	+0.077	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006105 vs ALDH5A1 — LSCC

Explore this scatter interactively →