Succinate metabolic process

Across TCGA cell cohorts, RNA activity of the Succinate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C12orf65, PRELID3A, and EOLA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C12orf65 grouped by Succinate metabolic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	C12orf65 →	-0.552	-1.246	.002	.001	3	5
SOFT_TISSUE	PRELID3A →	-0.938	-1.114	.004	.004	3	5
LIVER	EOLA1 →	+1.231	+1.232	<.001	.002	3	4
SKIN	BBX →	-0.732	-1.406	.001	<.001	3	4
BREAST	NXN →	-2.038	-0.954	.001	.002	3	4
BREAST	ESRP2 →	+2.150	+1.004	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C12orf65 by Succinate metabolic process activity — BONE

Explore this box plot interactively →