Succinyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Succinyl-CoA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLUH, NUDT8, and BZW2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinyl-CoA metabolic process activity versus CLUH in LSCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLUH →	+0.421	+0.064	<.001	<.001	3	7
COAD	NUDT8 →	+0.561	+0.048	<.001	<.001	3	6
BRCA	BZW2 →	+0.429	+0.059	<.001	<.001	3	6
PDAC	GPI →	+0.323	+0.052	<.001	<.001	3	6
LUAD	LRPPRC →	+0.493	+0.062	<.001	<.001	3	6
LUAD	POLDIP2 →	+0.327	+0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006104 vs CLUH — LSCC

Explore this scatter interactively →