Succinyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Succinyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPAR4, UBE3A, and IKBIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinyl-CoA metabolic process activity versus LPAR4 in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LPAR4 →	-0.709	-0.080	<.001	<.001	3	5
PDAC	UBE3A →	-0.314	-0.071	<.001	.003	3	4
COAD	IKBIP →	-0.634	-0.134	<.001	<.001	3	4
COAD	MORF4L1 →	-0.463	-0.109	.001	.003	3	4
LSCC	MT-ND2 →	+0.811	+0.144	<.001	.001	3	4
COAD	ACOT7 →	-0.421	-0.145	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006104 vs LPAR4 — GBM

Explore this scatter interactively →