Succinyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Succinyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MNDA, CCNG2, and POMGNT2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MNDA grouped by Succinyl-CoA metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MNDA →	-0.037	-0.863	.002	<.001	3	4
BLOOD_Leukemia	CCNG2 →	-1.197	-0.416	.009	<.001	3	4
OESOPHAGUS	POMGNT2 →	+1.150	+1.249	.002	.006	3	4
CNS	RLF →	-0.488	-1.127	<.001	<.001	3	4
CNS	TRIT1 →	-0.407	-1.025	.007	.002	3	4
BLOOD_Myeloma	IMP4 →	+0.819	+0.285	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MNDA by Succinyl-CoA metabolic process activity — BREAST

Explore this box plot interactively →