Succinyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Succinyl-CoA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OGDH, DLST, and SUCLG1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Succinyl-CoA metabolic process activity versus OGDH in SOFT_TISSUE (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OGDH →	+1.481	+0.334	<.001	<.001	3	17
PANCREAS	DLST →	+1.098	+0.251	<.001	<.001	3	15
LUNG_SCLC	SUCLG1 →	+1.045	+0.379	<.001	<.001	3	15
LARGE_INTESTINE	PFDN5 →	-1.559	-0.266	<.001	<.001	3	13
LARGE_INTESTINE	SUCLG2 →	+1.444	+0.262	.001	<.001	3	13
PANCREAS	PFDN6 →	-1.077	-0.155	.001	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006104 vs OGDH — SOFT_TISSUE

Explore this scatter interactively →