Isocitrate metabolic process

Across TCGA patient cohorts, RNA activity of the Isocitrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF84-DT, RAB5CP2, and PBXIP1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isocitrate metabolic process activity versus ZNF84-DT in BRCA (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF84-DT →	-0.170	-0.089	.001	.001	3	3
BRCA	RAB5CP2 →	-0.234	-0.076	<.001	.009	3	3
LUAD	PBXIP1 →	-0.532	-0.066	.003	.006	3	3
LUAD	MTCO2P16 →	-0.599	-0.066	.005	.007	3	3
OV	ZMYM2 →	-0.461	-0.088	.006	.006	3	3
OV	MBD5 →	-0.354	-0.061	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006102 vs ZNF84-DT — BRCA

Explore this scatter interactively →