Isocitrate metabolic process

Across TCGA cell cohorts, RNA activity of the Isocitrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF696, LNX2, and FERMT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF696 grouped by Isocitrate metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF696 →	+0.573	+0.942	.004	.001	3	4
SOFT_TISSUE	LNX2 →	+0.506	+1.011	.003	.005	3	4
BLOOD_Myeloma	FERMT1 →	-2.842	-2.108	<.001	<.001	3	4
OVARY	PTGR1 →	-1.866	-0.975	.009	.005	2	4
OVARY	IFI27 →	-4.055	-1.048	.003	.003	3	3
LUNG_SCLC	MARS1 →	+0.639	+1.085	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF696 by Isocitrate metabolic process activity — OVARY

Explore this box plot interactively →