Isocitrate metabolic process

Across TCGA cell cohorts, RNA activity of the Isocitrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDH3A, TMED3, and WDR61, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Isocitrate metabolic process activity versus IDH3A in BREAST (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IDH3A →	+1.256	+0.364	<.001	<.001	3	11
SKIN	TMED3 →	+0.924	+0.267	<.001	<.001	3	8
SKIN	WDR61 →	+0.943	+0.241	.001	.004	3	7
SKIN	CSK →	+0.742	+0.216	<.001	<.001	3	6
STOMACH	MIPEP →	+1.100	+0.210	.001	<.001	3	6
OESOPHAGUS	SLC25A6 →	+1.351	+0.299	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006102 vs IDH3A — BREAST

Explore this scatter interactively →