Citrate metabolic process

Across TCGA patient cohorts, RNA activity of the Citrate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACO2, ATP5F1A, and CCDC134, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrate metabolic process activity versus ACO2 in HNSC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ACO2 →	+0.457	+0.085	<.001	<.001	3	6
UCEC	ATP5F1A →	+0.250	+0.065	.008	.001	3	5
COAD	CCDC134 →	+0.270	+0.023	.004	.008	3	5
HNSC	TSC22D2 →	-0.370	-0.054	<.001	.001	3	5
GBM	ST13 →	+0.310	+0.050	.002	.001	3	5
LUAD	GGA1 →	+0.238	+0.046	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006101 vs ACO2 — HNSC

Explore this scatter interactively →