Citrate metabolic process

Across TCGA patient cohorts, RNA activity of the Citrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAT, LGI3, and IGSF10, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrate metabolic process activity versus OAT in CCRCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	OAT →	-0.335	-0.119	.002	<.001	3	3
GBM	LGI3 →	-0.880	-0.079	.006	.005	3	3
PDAC	IGSF10 →	-0.322	-0.088	.002	.002	3	3
HNSC	MAFA-AS1 →	-0.691	-0.081	<.001	<.001	3	3
OV	MAP4K3 →	-0.371	-0.099	.005	.007	3	3
GBM	ANK3 →	-0.918	-0.109	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006101 vs OAT — CCRCC

Explore this scatter interactively →