Citrate metabolic process

Across TCGA cell cohorts, RNA activity of the Citrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UEVLD, IL17RC, and TTLL12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UEVLD grouped by Citrate metabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	UEVLD →	-0.386	-0.416	.004	<.001	3	4
SOFT_TISSUE	IL17RC →	-1.095	-0.240	<.001	.003	3	4
SKIN	TTLL12 →	+0.641	+0.184	<.001	.006	3	4
BREAST	RBM19 →	+0.636	+0.203	.006	.002	3	4
BREAST	ATP10D →	-0.796	-0.322	.006	.001	3	4
BREAST	CAVIN1 →	-2.698	-0.292	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UEVLD by Citrate metabolic process activity — URINARY_TRACT

Explore this box plot interactively →