Citrate metabolic process

Across TCGA cell cohorts, RNA activity of the Citrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACO1, ACO2, and ACLY, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrate metabolic process activity versus ACO1 in KIDNEY (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ACO1 →	+1.432	+0.164	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	ACO2 →	+0.718	+0.088	<.001	<.001	3	12
OVARY	ACLY →	+0.889	+0.120	.001	.001	3	10
BLOOD_Lymphoma	SCFD2 →	+0.828	+0.077	.003	.001	3	9
OESOPHAGUS	POLDIP3 →	+1.078	+0.202	<.001	<.001	3	9
LIVER	DNAJB5 →	+1.447	+0.101	<.001	.001	2	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006101 vs ACO1 — KIDNEY

Explore this scatter interactively →