Citrate metabolic process

Across TCGA cell cohorts, RNA activity of the Citrate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACLY, PSMD10, and PIP4K2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrate metabolic process activity versus ACLY in STOMACH (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACLY →	+1.207	+0.201	.006	.001	3	7
PANCREAS	PSMD10 →	-0.768	-0.138	<.001	<.001	3	5
URINARY_TRACT	PIP4K2B →	+0.826	+0.177	.001	.002	3	5
STOMACH	SEMA7A →	-3.366	-0.183	.003	.007	3	4
STOMACH	RAD51D →	+0.793	+0.185	<.001	<.001	3	4
STOMACH	ITGAE →	-1.173	-0.195	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006101 vs ACLY — STOMACH

Explore this scatter interactively →