Citrate metabolic process

Across TCGA cell cohorts, RNA activity of the Citrate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACLY, NME2, and EEF2, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Citrate metabolic process activity versus ACLY in SOFT_TISSUE (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACLY →	+1.475	+0.265	<.001	<.001	3	16
BONE	NME2 →	+1.010	+0.168	.005	.002	3	9
CNS	EEF2 →	+1.056	+0.163	.003	.001	3	9
STOMACH	PSME3 →	+1.608	+0.208	<.001	.002	3	8
STOMACH	FASN →	+2.131	+0.187	.002	.001	1	10
LUNG_SCLC	ARHGDIA →	+1.071	+0.127	.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006101 vs ACLY — SOFT_TISSUE

Explore this scatter interactively →