Tricarboxylic acid cycle

Across TCGA patient cohorts, RNA activity of the Tricarboxylic acid cycle pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP7D1_T97, SORBS2, and UTP15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tricarboxylic acid cycle activity versus MAP7D1_T97 in LUAD (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAP7D1_T97 →	-0.338	-0.029	.001	.001	3	6
CCRCC	SORBS2 →	+0.628	+0.059	<.001	<.001	3	5
GBM	UTP15 →	-0.394	-0.070	<.001	<.001	3	5
GBM	HDLBP_S944 →	-0.848	-0.053	<.001	<.001	3	5
GBM	SRRM1_S636 →	-0.395	-0.051	<.001	.001	3	5
GBM	DDX47 →	-0.344	-0.052	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006099 vs MAP7D1_T97 — LUAD

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