Tricarboxylic acid cycle

Across TCGA patient cohorts, RNA activity of the Tricarboxylic acid cycle pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT2P1, RPSAP15, and TERF1P4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tricarboxylic acid cycle activity versus MT2P1 in BRCA (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MT2P1 →	-1.263	-0.142	.001	.003	2	5
HNSC	RPSAP15 →	-0.490	-0.079	.001	.007	3	4
CCRCC	TERF1P4 →	-0.079	-0.120	.001	.007	3	3
COAD	PHF8 →	+0.619	+0.105	.008	.001	3	3
COAD	RSL24D1P6 →	+0.416	+0.104	.003	.002	3	3
CCRCC	MTRES1 →	+0.251	+0.159	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006099 vs MT2P1 — BRCA

Explore this scatter interactively →