Tricarboxylic acid cycle

Across TCGA cell cohorts, RNA activity of the Tricarboxylic acid cycle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD1LG2, ABCA1, and SRPX2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDCD1LG2 grouped by Tricarboxylic acid cycle-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PDCD1LG2 →	-0.812	-0.405	<.001	.002	3	6
OVARY	ABCA1 →	-1.151	-0.672	<.001	<.001	3	5
CNS	SRPX2 →	-1.705	-1.181	.006	<.001	3	5
BREAST	LOXL2 →	-3.140	-0.625	<.001	.001	3	5
PANCREAS	CASP1 →	-2.351	-0.260	.004	.005	2	6
BREAST	TGFB1I1 →	-2.339	-0.774	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDCD1LG2 by Tricarboxylic acid cycle activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →