Tricarboxylic acid cycle

Across TCGA cell cohorts, RNA activity of the Tricarboxylic acid cycle pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHF13, GDF15, and ANXA4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tricarboxylic acid cycle activity versus PHF13 in LUNG_NSCLC_LUAD (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PHF13 →	-0.786	-0.285	.001	<.001	3	6
PANCREAS	GDF15 →	+2.182	+0.205	.002	.001	3	6
BLOOD_Lymphoma	ANXA4 →	+2.269	+0.174	.008	.002	3	6
BREAST	NIPAL2 →	+1.243	+0.268	<.001	<.001	3	6
BREAST	STMN1 →	-1.178	-0.200	<.001	.002	3	6
LUNG_NSCLC_LUAD	MGST2 →	+1.786	+0.232	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006099 vs PHF13 — LUNG_NSCLC_LUAD

Explore this scatter interactively →