Glycolytic process

Across TCGA patient cohorts, RNA activity of the Glycolytic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, ADAM12, and MXRA5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycolytic process activity versus FN1 in BRCA (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FN1 →	-1.179	-0.127	<.001	.009	3	5
PDAC	ADAM12 →	-0.548	-0.152	.006	<.001	3	5
OV	MXRA5 →	-1.034	-0.143	.002	.006	3	4
OV	COL12A1 →	-1.075	-0.128	.001	.004	3	4
OV	XPO6 →	-0.345	-0.180	.007	.001	3	4
PDAC	DSE →	-0.506	-0.239	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006096 vs FN1 — BRCA

Explore this scatter interactively →