Glycolytic process

Across TCGA cell cohorts, RNA activity of the Glycolytic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAGH, CLCN7, and KLHL25, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HAGH grouped by Glycolytic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HAGH →	-0.724	-0.395	<.001	.005	3	5
LUNG_NSCLC_LUAD	CLCN7 →	-0.922	-0.469	.001	.005	3	5
BREAST	KLHL25 →	-0.685	-0.237	.002	.003	3	4
BREAST	C2orf72 →	-1.542	-0.336	.004	.009	3	4
SKIN	SUCLG2 →	+0.582	+0.306	.001	.004	3	4
OVARY	NME9 →	-0.404	-0.227	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HAGH by Glycolytic process activity — SKIN

Explore this box plot interactively →