Pyruvate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyruvate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASB7, SULF1, and THBS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyruvate metabolic process activity versus ASB7 in PDAC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ASB7 →	-0.507	-0.362	<.001	<.001	3	4
BRCA	SULF1 →	-1.305	-0.221	<.001	<.001	3	4
BRCA	THBS2 →	-1.131	-0.134	.001	.003	3	4
BRCA	COL11A1 →	-1.430	-0.171	.002	.001	3	4
HNSC	MEGF11 →	-0.618	-0.146	.001	.004	3	3
OV	ERMAP →	-0.620	-0.218	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006090 vs ASB7 — PDAC

Explore this scatter interactively →