Pyruvate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyruvate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2B3, NDC1, and KIF2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2B3 grouped by Pyruvate metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EIF2B3 →	+0.831	+0.188	.006	.004	3	5
STOMACH	NDC1 →	+0.837	+0.242	.003	.003	3	5
STOMACH	KIF2C →	+0.869	+0.213	<.001	.002	3	4
SOFT_TISSUE	NGLY1 →	+0.876	+0.289	.001	<.001	3	4
OVARY	SPRY1 →	-3.115	-0.277	<.001	<.001	3	4
KIDNEY	UGT2B7 →	-2.590	-0.302	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2B3 by Pyruvate metabolic process activity — PANCREAS

Explore this box plot interactively →