Pyruvate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyruvate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFS2, MRPS16, and ALAS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyruvate metabolic process activity versus NDUFS2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NDUFS2 →	+0.669	+0.327	.003	<.001	3	7
LUNG_NSCLC_LUAD	MRPS16 →	+0.594	+0.155	.002	.002	3	5
BLOOD_Leukemia	ALAS1 →	+0.740	+0.126	.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	NDUFV2 →	+0.742	+0.220	.006	.006	3	5
SOFT_TISSUE	TKT →	+1.203	+0.179	.002	.005	3	5
BREAST	FAHD1 →	+0.732	+0.153	.003	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006090 vs NDUFS2 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →