Lactate metabolic process

Across TCGA patient cohorts, RNA activity of the Lactate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFKFB2, NPM1, and RPL7AP15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactate metabolic process activity versus PFKFB2 in GBM (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PFKFB2 →	+0.731	+0.198	.005	.002	3	7
CCRCC	NPM1 →	-0.252	-0.118	.007	.009	3	4
PDAC	RPL7AP15 →	+0.791	+0.182	.003	<.001	3	4
GBM	REPS2 →	+1.035	+0.158	.001	.004	2	5
UCEC	PTTG1 →	-1.094	-0.183	.001	<.001	3	3
UCEC	PBK →	-1.136	-0.181	.002	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006089 vs PFKFB2 — GBM

Explore this scatter interactively →