Lactate metabolic process

Across TCGA cell cohorts, RNA activity of the Lactate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A4RG, SNX4, and GTF2E1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC2A4RG grouped by Lactate metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC2A4RG →	+1.108	+1.118	.008	.003	3	4
LUNG_NSCLC_LUSC	SNX4 →	+0.653	+1.376	.001	<.001	3	4
BLOOD_Leukemia	GTF2E1 →	+0.600	+0.904	.002	.003	3	4
KIDNEY	KMT2B →	+0.672	+0.815	.004	.003	3	4
LIVER	ETV2 →	+0.500	+0.345	.001	.002	3	4
STOMACH	TNIK →	-2.345	-1.456	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC2A4RG by Lactate metabolic process activity — STOMACH

Explore this box plot interactively →