Lactate metabolic process

Across TCGA cell cohorts, RNA activity of the Lactate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM1A, TBX3, and NT5E, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM1A grouped by Lactate metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KDM1A →	-0.381	-0.085	<.001	.002	3	6
BREAST	TBX3 →	-0.109	-0.196	.008	<.001	3	5
BREAST	NT5E →	+0.089	+0.127	.006	.002	3	5
STOMACH	BCS1L →	-0.308	-0.247	<.001	<.001	3	4
BREAST	TUBA3D →	+0.218	+0.187	.004	<.001	3	4
KIDNEY	KCNJ14 →	-0.147	-0.091	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM1A by Lactate metabolic process activity — OVARY

Explore this box plot interactively →