Lactate metabolic process

Across TCGA cell cohorts, RNA activity of the Lactate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDHB, KRT18, and SOD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lactate metabolic process activity versus LDHB in STOMACH (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LDHB →	+5.421	+0.198	.002	.006	3	6
URINARY_TRACT	KRT18 →	-2.744	-0.614	.009	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	SOD1 →	+0.879	+0.150	.002	.002	3	5
SKIN	CBR3 →	+1.220	+0.155	<.001	.001	3	5
SKIN	KRT8 →	-2.133	-0.171	.003	.002	3	5
KIDNEY	VGLL1 →	-0.133	-0.185	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006089 vs LDHB — STOMACH

Explore this scatter interactively →