Acetyl-CoA biosynthetic process from pyruvate

Across TCGA patient cohorts, RNA activity of the Acetyl-CoA biosynthetic process from pyruvate pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID1, PDK3, and NES_S934, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetyl-CoA biosynthetic process from pyruvate activity versus NID1 in OV (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NID1 →	+0.476	+0.030	.003	.005	3	6
HNSC	PDK3 →	+0.307	+0.083	<.001	.001	3	6
PDAC	NES_S934 →	+0.518	+0.046	.003	<.001	3	6
GBM	MPP1 →	+0.316	+0.045	.003	.002	3	5
GBM	RPL10A →	-0.192	-0.062	<.001	.001	3	5
HNSC	TNS1 →	+0.442	+0.082	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006086 vs NID1 — OV

Explore this scatter interactively →