Acetyl-CoA biosynthetic process from pyruvate

Across TCGA patient cohorts, RNA activity of the Acetyl-CoA biosynthetic process from pyruvate pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01138, PDE4DIPP6, and TRAF3IP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetyl-CoA biosynthetic process from pyruvate activity versus LINC01138 in BRCA (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01138 →	-0.950	-0.218	<.001	<.001	3	4
UCEC	PDE4DIPP6 →	-0.650	-0.144	<.001	.002	3	4
UCEC	TRAF3IP2 →	-0.613	-0.141	<.001	.001	3	4
PDAC	PLEK2 →	-0.652	-0.165	.001	<.001	3	3
PDAC	EHD4 →	-0.288	-0.142	.004	.004	3	3
PDAC	SEMA7A →	-0.794	-0.180	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006086 vs LINC01138 — BRCA

Explore this scatter interactively →