Acetyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Acetyl-CoA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPTBN1, DDAH1, and ACAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetyl-CoA metabolic process activity versus SPTBN1 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPTBN1 →	+0.367	+0.045	<.001	<.001	3	6
HNSC	DDAH1 →	+0.627	+0.051	<.001	.002	3	6
GBM	ACAT1 →	+0.351	+0.049	<.001	.001	3	6
GBM	MTARC2 →	+0.537	+0.052	<.001	<.001	3	6
GBM	FN3K →	+0.514	+0.055	.001	<.001	3	6
GBM	FOSL2_S230 →	-0.351	-0.029	.002	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006084 vs SPTBN1 — BRCA

Explore this scatter interactively →