Acetyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Acetyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGCS1, NMRAL2P, and PDP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetyl-CoA metabolic process activity versus HMGCS1 in LSCC (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HMGCS1 →	+0.976	+0.203	<.001	<.001	3	4
LSCC	NMRAL2P →	+1.967	+0.134	.003	.004	3	4
LSCC	PDP2 →	+0.478	+0.167	<.001	<.001	3	4
LSCC	GOT2 →	+0.837	+0.217	<.001	<.001	3	4
LSCC	RUFY4 →	-0.443	-0.119	<.001	.003	3	4
LSCC	NCR1 →	-0.458	-0.207	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006084 vs HMGCS1 — LSCC

Explore this scatter interactively →