Acetyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Acetyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLAT, UCK2, and ACAT1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acetyl-CoA metabolic process activity versus DLAT in LUNG_NSCLC_LUSC (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DLAT →	+0.971	+0.335	.002	.001	3	9
UPPER_AERODIGESTIVE_TRACT	UCK2 →	+1.054	+0.288	<.001	<.001	2	8
UPPER_AERODIGESTIVE_TRACT	ACAT1 →	+1.667	+0.341	.006	.001	3	7
OESOPHAGUS	NDUFS2 →	+0.779	+0.255	.001	.003	2	8
PANCREAS	CMPK2 →	-1.404	-0.138	<.001	.001	3	7
OVARY	TRAP1 →	+0.663	+0.193	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006084 vs DLAT — LUNG_NSCLC_LUSC

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