Glycerol-3-phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Glycerol-3-phosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GPD1, ABLIM1_S706, and MAPRE3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerol-3-phosphate metabolic process activity versus GPD1 in COAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GPD1 →	+0.956	+0.065	<.001	<.001	3	6
LSCC	ABLIM1_S706 →	+0.643	+0.083	.001	<.001	3	5
GBM	MAPRE3 →	+0.327	+0.049	<.001	.001	3	5
BRCA	ABLIM3 →	+0.540	+0.051	<.001	<.001	3	5
COAD	TOMM22 →	-0.143	-0.027	.004	.008	3	4
LSCC	GPAT3_S68 →	+1.207	+0.090	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006072 vs GPD1 — COAD

Explore this scatter interactively →