Glycerol-3-phosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Glycerol-3-phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM7, ANPEP, and TNFAIP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerol-3-phosphate metabolic process activity versus TRIM7 in HNSC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM7 →	+0.571	+0.123	<.001	.009	3	4
CCRCC	ANPEP →	+1.133	+0.198	.004	<.001	3	4
OV	TNFAIP3 →	+1.028	+0.152	.004	.009	3	4
OV	XPNPEP2 →	+0.299	+0.121	<.001	.001	3	4
OV	KLF2 →	+0.903	+0.103	<.001	.008	3	4
OV	C16orf54 →	+0.539	+0.168	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006072 vs TRIM7 — HNSC

Explore this scatter interactively →