Glycerol-3-phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Glycerol-3-phosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK4, RTP2, and ACTG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAMK4 grouped by Glycerol-3-phosphate metabolic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CAMK4 →	-0.251	-1.264	<.001	<.001	3	4
URINARY_TRACT	RTP2 →	+0.233	+0.134	.005	.006	3	3
BONE	ACTG1 →	-0.335	-1.248	.002	<.001	3	3
BONE	ZFAND6 →	-0.472	-1.683	.004	<.001	3	3
LUNG_NSCLC_LUSC	C3orf38 →	-0.186	-0.055	.003	.001	3	3
BLOOD_Lymphoma	CNGA1 →	+0.300	+0.173	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAMK4 by Glycerol-3-phosphate metabolic process activity — BONE

Explore this box plot interactively →