Glycerol-3-phosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Glycerol-3-phosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A14, KLF7, and CANT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerol-3-phosphate metabolic process activity versus S100A14 in SKIN (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	S100A14 →	+0.333	+0.204	.001	.005	3	4
SOFT_TISSUE	KLF7 →	+1.603	+1.486	.006	<.001	3	3
OESOPHAGUS	CANT1 →	+1.342	+0.217	.007	.005	3	3
URINARY_TRACT	SSX2IP →	-0.935	-1.620	.005	<.001	3	3
SKIN	HIRA →	-0.484	-0.147	.001	.009	3	3
PANCREAS	EIF3I →	-0.675	-0.189	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006072 vs S100A14 — SKIN

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