Uronic acid metabolic process

pathway activity — cross-omics
GO:0006063Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Uronic acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R12A_S995, ZYX, and IKBIP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCPPP1R12A_S995 →-0.490-0.133<.001<.00137
LSCCZYX →-0.297-0.129<.001<.00136
GBMIKBIP →-0.724-0.100<.001<.00136
LSCCVIM →-0.300-0.103<.001<.00136
LSCCZYX_S344 →-0.485-0.121<.001.00136
LSCCMOXD1 →-0.683-0.160<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration