N-acetylneuraminate metabolic process

Across TCGA patient cohorts, RNA activity of the N-acetylneuraminate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL10RA, NCKAP1L, and GPR65, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylneuraminate metabolic process activity versus IL10RA in UCS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	IL10RA →	+1.450	+0.054	<.001	<.001	3	33
SCLC	NCKAP1L →	+2.720	+0.133	<.001	<.001	3	33
LAML	GPR65 →	+1.207	+0.078	<.001	<.001	3	33
LAML	TLR8 →	+1.556	+0.053	<.001	<.001	3	32
SARC	CRTAM →	+1.079	+0.050	<.001	<.001	3	32
SCLC	DOCK2 →	+2.201	+0.174	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006054 vs IL10RA — UCS

Explore this scatter interactively →