N-acetylneuraminate metabolic process

Across TCGA patient cohorts, RNA activity of the N-acetylneuraminate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RENBP, WIPF1, and DAB2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylneuraminate metabolic process activity versus RENBP in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RENBP →	+0.464	+0.047	.003	.006	3	8
COAD	WIPF1 →	+0.362	+0.038	<.001	<.001	3	7
OV	DAB2 →	+0.426	+0.048	<.001	<.001	3	6
OV	AIF1 →	+0.526	+0.043	.001	.002	3	6
OV	LCP2 →	+0.368	+0.045	.009	.004	2	7
OV	LIMD2 →	+0.690	+0.047	.002	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006054 vs RENBP — OV

Explore this scatter interactively →