N-acetylneuraminate metabolic process

Across TCGA patient cohorts, RNA activity of the N-acetylneuraminate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF4, FCRL5, and PTPN11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylneuraminate metabolic process activity versus IRF4 in HNSC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IRF4 →	+0.811	+0.092	<.001	.001	3	5
HNSC	FCRL5 →	+1.001	+0.117	<.001	<.001	3	5
LSCC	PTPN11 →	-0.451	-0.131	<.001	<.001	3	5
LSCC	DERL3 →	+0.691	+0.118	<.001	<.001	3	5
LSCC	AMPD1 →	+0.468	+0.112	<.001	<.001	3	5
LSCC	SUCLA2 →	-0.308	-0.104	.009	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006054 vs IRF4 — HNSC

Explore this scatter interactively →