N-acetylneuraminate metabolic process

Across TCGA cell cohorts, RNA activity of the N-acetylneuraminate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA20, EEF1A2, and CCDC47, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPATA20 grouped by N-acetylneuraminate metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SPATA20 →	-1.040	-0.859	<.001	<.001	3	5
PANCREAS	EEF1A2 →	-4.068	-1.154	<.001	.003	3	4
PANCREAS	CCDC47 →	-0.733	-0.991	.001	.001	3	4
BONE	CCDC144A →	+2.145	+1.502	<.001	.003	3	4
BLOOD_Lymphoma	GALK1 →	-1.385	-1.631	.008	<.001	3	4
KIDNEY	XPR1 →	+1.169	+1.547	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPATA20 by N-acetylneuraminate metabolic process activity — BREAST

Explore this box plot interactively →