N-acetylneuraminate metabolic process

Across TCGA cell cohorts, RNA activity of the N-acetylneuraminate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NANS, CMAS, and NAGK, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-acetylneuraminate metabolic process activity versus NANS in BREAST (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NANS →	+1.839	+1.414	.001	<.001	3	15
BREAST	CMAS →	+1.381	+0.892	<.001	.003	3	12
URINARY_TRACT	NAGK →	+2.167	+1.466	.004	.009	3	11
URINARY_TRACT	CMPK1 →	+2.415	+1.743	.003	.002	3	9
SOFT_TISSUE	CAND1 →	+0.857	+1.437	.003	.003	3	9
BONE	GADD45GIP1 →	-0.640	-1.009	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006054 vs NANS — BREAST

Explore this scatter interactively →